N-[Tosyl-D-Prolinyl]Amino-Ethanethiol

N-[Tosyl-D-Prolinyl]Amino-Ethanethiol is a synthetic small molecule belonging to the class of N,N-disubstituted p-toluenesulfonamides. It has been studied as an experimental compound, primarily for its activity as an inhibitor of thymidylate synthase, an essential enzyme in pyrimidine metabolism. Thymidylate synthase inhibition is a validated anticancer strategy due to its role in DNA synthesis and repair. The compound was notably used in structure-based drug design studies employing "tethering" strategies to identify and optimize weak-binding fragments into more potent inhibitors. It has not been approved for clinical use and remains at the experimental stage[1][2][3][7].

Other names

N-(Tosyl-D-Prolinyl)Amino-Ethanethiol(2R)-1-(4-methylbenzenesulfonyl)-N-(2-sulfanylethyl)pyrrolidine-2-carboxamide1-[(4-Methylphenyl)sulfonyl]-N-(2-sulfanylethyl)-D-prolinamideSCHEMBL4308892SCHEMBL-4308892SCHEMBL 4308892